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“Collaboration. Collaboration. Collaboration.”

Acuitas Therapeutics’ Dr. Ghania Chikh shares what it takes to make a scientific breakthrough

Baby KJ was born with a rare genetic liver disorder. His body couldn’t rid itself of ammonia, which, if it reached his brain, could have proved fatal. “He was four months old,” says Dr. Ghania Chikh, Senior Director, Vaccine Development at Vancouver biotech company Acuitas Therapeutics, Inc. “He couldn’t have a liver transplant, and he couldn’t leave the hospital.”

The hospital in question, Children’s Hospital of Philadelphia, together with the University of Pennsylvania, approached Acuitas Therapeutics for help. “They said, ‘Would you be willing to make an LNP with an mRNA to correct this?’”

LNP — lipid nanoparticles — are microscopic, fat-based spheres which enable delicate messenger RNA (mRNA) to be injected into the body without breaking down. A quick recap of high school biology: DNA makes RNA, RNA makes proteins.

What the medical teams did next was a world-first.

Within a few months, they developed, manufactured, and delivered a bespoke gene therapy for Baby KJ, using the LNP from Acuitas. In June 2025, after 307 days in hospital, Baby KJ was finally able to go home.

The news made global headlines from Time magazine to CBC — which reported “U.S. baby healed with tailor-made therapy using Canadian technology.” As Dr. Chikh says, “It was collaboration, collaboration, collaboration.”

How a fear of needles decided her fate

Dr. Chikh, who joined Acuitas in late 2023, thought she was destined to be a physician — until a watershed moment during her first year of university. “My younger sister was sick,” she explains, “and my brother, who is ten years older than me, was a physician. He was treating her and showing me how to make an intramuscular injection, when I fainted!”

Reminiscing about the incident, Dr. Chikh traces her motivations for entering the medical field back to her uncle who, alongside her brother, was also a physician. “I was just fascinated by how my uncle could relieve patients’ pain.” She recalls how he would consult the equivalent of the Compendium of Pharmaceuticals and Specialties (CPS)publication here in Canada, which details medical conditions and drug therapies. “I was always curious,” she says. She wanted to know how those drugs made it to clinic and, ultimately, to patients’ bedsides.

More than 24 years of drug development experience later, it’s clear how much Dr. Chikh still loves what she describes as the “puzzle” of understanding diseases and figuring out how to treat them. In fact, she completed her PhD thesis on developing a cancer vaccine using LNP. Today, she splits her time between working from her home office in Ottawa, and onsite at Acuitas in Vancouver, where she also loves to hike.

Words of encouragement for young scientists

In April 2024, Dr. Chikh provided the opening remarks at Science World’s Girls and STEAM studio — a morning of interactive workshops held at Science World, for participants aged 12 – 14. She tells of how, afterwards, a mom and her daughter came up to her and asked in an awe-struck tone, “How do I become a scientist?” To which, Dr. Chikh enthused, “It’s going to be even easier for you to be a scientist nowadays! So, if you want it, you can get there.”

Her advice for any aspiring scientist is this: “Believe in yourself, especially when others might not believe in you. Science has unlimited potential. Really, we have only scratched the surface — even after years and years of research and drug discovery.” She adds: “And finally, the biggest breakthrough will never come from a single lab, but from worldwide collaboration. So really, we need you.

The future is getting nerdier

That’s right, we need kids from all walks of life entering STEAM careers (science, technology, engineering, art & design, and math). Now, thanks to the continued support of Acuitas, that’s becoming a reality. The company’s generous contributions have designated Acuitas as the Presenting Partner of Science World’sFuture Science Leadersprogram, a Major Partner of both Super Science Club and Girls and STEAM, presented by STEMCELLTechnologies, and a Partner in Human Health content. All of which contributes to a landscape in which more young people can see themselves in STEAM jobs.

In chatting with Dr. Chikh, it’s evident how passionate and optimistic she is about the future of LNP technology and, indeed, science as a whole. Dr. Chikh cites the Nobel Prize-winning physicist and chemist Marie Curie as a guiding light, reminding herself how much the iconic female scientist had to overcome. “When you think about all she went through — being poor, being rejected, being a woman [in the late 19th and early 20th century], it’s just unbelievable.” She adds with a laugh, “So, for me nowadays, I should be able to accomplish much more!”

This includes, being part of the team that delivered the world’s first customized gene-editing therapy to save a baby’s life. Marie Curie would be proud.

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Survivors

Artist: Jeff Kulak

Jeff is a senior graphic designer at Science World. His illustration work has been published in the Walrus, The National Post, Reader’s Digest and Chickadee Magazine. He loves to make music, ride bikes, and spend time in the forest.

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Egg BB

Artist: Jeff Kulak

Jeff is a senior graphic designer at Science World. His illustration work has been published in the Walrus, The National Post, Reader’s Digest and Chickadee Magazine. He loves to make music, ride bikes, and spend time in the forest.

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Comet Crisp

Artist: Jeff Kulak

Jeff is a senior graphic designer at Science World. His illustration work has been published in the Walrus, The National Post, Reader’s Digest and Chickadee Magazine. He loves to make music, ride bikes, and spend time in the forest.

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Artist: Michelle Yong

Michelle is a designer with a focus on creating joyful digital experiences! She enjoys exploring the potential forms that an idea can express itself in and helping then take shape.

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Buddy the T-Rex

Artist: Michelle Yong

Michelle is a designer with a focus on creating joyful digital experiences! She enjoys exploring the potential forms that an idea can express itself in and helping then take shape.

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Geodessy

Artist: Michelle Yong

Michelle is a designer with a focus on creating joyful digital experiences! She enjoys exploring the potential forms that an idea can express itself in and helping then take shape.

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Artist: Ty Dale

From Canada, Ty was born in Vancouver, British Columbia in 1993. From his chaotic workspace he draws in several different illustrative styles with thick outlines, bold colours and quirky-child like drawings. Ty distils the world around him into its basic geometry, prompting us to look at the mundane in a different way.

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Western Dinosaur

Artist: Ty Dale

From Canada, Ty was born in Vancouver, British Columbia in 1993. From his chaotic workspace he draws in several different illustrative styles with thick outlines, bold colours and quirky-child like drawings. Ty distils the world around him into its basic geometry, prompting us to look at the mundane in a different way.

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Time-Travel T-Rex

Artist: Ty Dale

From Canada, Ty was born in Vancouver, British Columbia in 1993. From his chaotic workspace he draws in several different illustrative styles with thick outlines, bold colours and quirky-child like drawings. Ty distils the world around him into its basic geometry, prompting us to look at the mundane in a different way.